For Research Purposes Only — 99%+ Purity Guaranteed — USA Sourced
Tesamorelin and Ipamorelin is a research peptide blend designed to explore synergistic activation of the growth hormone axis through dual receptor mechanisms. Tesamorelin, a stabilized GHRH analog, stimulates cAMP/PKA-mediated GH synthesis, while Ipamorelin acts as a selective ghrelin receptor (GHS-R1a) agonist, triggering calcium-dependent signaling. This combination is utilized in studies examining pituitary receptor cross-talk, pulsatile hormone release, and peptide-mediated endocrine regulation.
For research use only. Not for human consumption.
References:
Teichman SL et al., J Clin Endocrinol Metab, 2006 91(2):479–487
Bowers CY et al., Endocrinology, 1990 126(2):1165–1171
Kojima M et al., Nature, 1999 402(6762):656–660
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This product is intended for laboratory research purposes only. Not for human consumption, veterinary, or medical use.
Tesamorelin is a growth hormone releasing hormone analog that has been shown to increase IGF-1 levels in men by an average of 181 micrograms/liter. It binds and stimulates human GHRH receptors with similar potency as endogenous GHRH. It has a host of other benefits including nootropic effects and reducing triglycerides. Tesamorelin research has subsequently been shown to decrease carotid intima media thickness (cIMT), visceral adipose tissue (VAT), and C-reactive proteins (CRP) in a recent study. It has not been shown to significantly affect other pituitary hormones and their respective mechanisms in the body. Additionally, studies have shown it to improve cognitive function for healthy older adults and also for people with mild cognitive impairment who are at an increased risk of progressing to Alzheimer’s disease.
Ipamorelin is a selective GH-Secretagogue and ghrelin receptor agonist. The potency of ghrelin stimulation can be compared to GHRP6 with less appetite stimulation properties. However, unlike other GH-Secretagogues this pentapeptide doesn’t release the same volumes of cortisol, acetylcholine, prolactin and aldosterone. It is for this reason Ipamorelin has been considered the first selective GH-Secretagogue.
By combining both ipamorelin and tesamorelin, it may be possible to produce enhanced effects because each peptide stimulates the growth hormone axis via two different mechanisms. Together, they both work synergistically to stimulate the pituitary gland to produce and secrete your own natural growth hormone at more youthful levels. Research has shown that the net effect of combining both of these peptides results in better deep sleep, reduced triglycerides, VAT, and cIMT, improved cognition, and overall better metabolic function.
Ipamorelin and Tesamorelin exhibits minimal side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. Ipamorelin and Tesamorelin are for sale at Peptide Sciences is limited to educational and scientific research only, not for human consumption. Only buy Ipamorelin and Tesamorelin if you are a licensed researcher.
